OIR - parametric computation of high-order interactions

A Framework for the Time- and Frequency-Domain Assessment of High-Order Interactions in Brain and Physiological Networks



While the standard network description of complex systems is based on quantifying the link between pairs of system units, higher-order interactions (HOIs) involving three or more units often play a major role in governing the collective network behavior.
This toolbox introduces an approach to quantify pairwise and HOIs for multivariate rhythmic processes interacting across multiple time scales. The toolbox computes the so-called O-information rate (OIR) as a new metric to assess HOIs for multivariate time series, and implements several functions to decompose the OIR into measures quantifying Granger-causal and instantaneous influences, as well as to expand all measures in the frequency domain. The framework exploits the spectral representation of vector autoregressive and state-space models to assess the synergistic and redundant interaction among groups of processes, both in specific bands of biological interest and in the time domain after whole-band integration.
The toolbox contains both simulations showing how the spectral OIR can highlight redundant and synergistic HOIs emerging at specific frequencies, which cannot be detected using time-domain measures, and exemplary applications to physiological time series, i.e. heart period, arterial pressure and respiration variability measured in a healthy subject during a protocol of paced breathing, and electrocorticographic signals acquired in an animal experiment during anesthesia.
The proposed framework allows a hierarchically-organized evaluation of time- and frequency-domain interactions in dynamic networks mapped by multivariate time series, and its high flexibility and scalability make it suitable for the investigation of networks beyond pairwise interactions in neuroscience, physiology and many other fields.

OIRsimu_img


DOWNLOAD: Zip file with all scripts and functions: OIR.zip

The code is provided free of charge. It is neither exhaustively tested nor particularly well documented. The authors accept no liability for its use. Use, modification and redistribution of the code is allowed in any way users see fit. Authors ask only that authorship is acknowledged and ref. [1] is cited upon utilization of the code in integral or partial form.

DISCLAIMER OF WARRANTIES AND LIMITATION OF LIABILITY The code is supplied as is and all use is at your own risk. The authors disclaim all warranties of any kind, either express or implied, as to the softwares, including, but not limited to, implied warranties of fitness for a particular purpose, merchantability or non - infringement of proprietary rights. Neither this agreement nor any documentation furnished under it is intended to express or imply any warranty that the operation of the software will be error - free. Under no circumstances shall the authors of the softwares provided here be liable to any user for direct, indirect, incidental, consequential, special, or exemplary damages, arising from the software, or user' s use or misuse of the softwares. Such limitation of liability shall apply whether the damages arise from the use or misuse of the data provided or errors of the software.

References:

L Faes, G Mijatovic, Y Antonacci, R Pernice, C Barą, L Sparacino, M Sammartino, A Porta, D Marinazzo, S Stramaglia 'A Framework for the Time- and Frequency-Domain Assessment of High-Order Interactions in Brain and Physiological Networks' submitted, 2022; ARxiv preprint